Crohn's disease & IBD
Moderate evidencePatient-reported relief of pain, appetite loss, nausea, and inflammation is consistent across surveys. Small clinical trials have shown symptom improvement and quality-of-life gains, though long-term inflammation outcomes are still being studied.
Chronic pain
Strong evidenceThe National Academies of Sciences (2017) found 'substantial evidence' that cannabis is effective for chronic pain in adults. Often used to reduce opioid reliance.
Chemotherapy-induced nausea & vomiting
Strong evidenceDecades of evidence support antiemetic effects, including for chemotherapy patients. FDA-approved synthetic cannabinoids (dronabinol, nabilone) exist for this exact use.
Multiple sclerosis (spasticity)
Strong evidenceStrong evidence that oral cannabinoids reduce patient-reported MS spasticity. Sativex (nabiximols) is approved in many countries.
Pediatric epilepsy (Dravet, Lennox-Gastaut)
Strong evidenceEpidiolex (purified CBD) is FDA-approved for these rare seizure disorders and has dramatically reduced seizure frequency in many patients.
PTSD
Moderate evidenceMany veterans and trauma survivors report sleep and hypervigilance improvements. Clinical research expanding, with several controlled trials underway.
Anxiety
Moderate evidenceCBD has shown anxiolytic effects in trials. THC effects are dose-dependent — low doses may help, higher doses may worsen anxiety in some.
Sleep disorders
Moderate evidenceMixed but generally positive evidence for short-term sleep onset; long-term effects on sleep architecture less clear.
Cancer cachexia & appetite loss
Moderate evidenceStrong appetite-stimulating effects well-documented; quality-of-life benefits for patients undergoing aggressive treatment.
Inflammatory skin conditions
Emerging evidenceTopical cannabinoids show early promise in eczema, psoriasis, and atopic dermatitis. More research needed.
Migraine & cluster headache
Emerging evidenceObservational studies report meaningful reductions in frequency and intensity; randomized trials are catching up.